We demonstrate that a substantial portion of subarachnoid CSF cycles through the brain interstitial space. The cerebrospinal fluid (CSF) functions as a sink for brain extracellular solutes, but it is not clear how solutes from the brain interstitium move from the parenchyma to the CSF. Animation depicting the role of paravascular CSF influx in interstitial solute clearance from the brain.īecause it lacks a lymphatic circulation, the brain must clear extracellular proteins by an alternative mechanism. Direct visualization of para-arterial influx of subarachnoid CSF tracer into the brain parenchyma. Schematic diagram of paravascular and interstitial bulk flow pathways. Measurement of interstitial solute clearance from the brain.įig. Differential expression of AQP4 in periarterial versus perivenous astrocytes.įig.
Visualization of paravascular accumulation of tracer and the Virchow-Robin space in wild-type and Aqp4-null mice.įig. Intracisternally and intraparenchymally injected tracer shares the same paravenous drainage pathway.įig. CSF does not enter the brain parenchyma along paravenous pathways.įig. In vivo imaging of para-arterial influx of small– and large–molecular weight tracers.įig.
Measurement of subarachnoid CSF entry into the brain parenchyma.įig.
Quantification of fluorescent CSF tracer distribution within the brain parenchyma.įig. You must retrieve the Peng Treasure during this part of the story, as you won’t be able to make it back there during the later parts of the game once you’ve interacted with the “Red Marker” to move on from chapter 11, the Peng Treasure is no longer accessible.Supplementary Data: Fig. Open up the leftmost locker and you will find the Peng Treasure. Move the boxes to reveal two lockers and a Peng poster hanging next to them. Here, you will see two large storage boxes that you can move with your Kinesis ability. Get out of the lift and then immediately take a left behind the elevator. Take the cargo lift down like the game wants you to do and make your way down to the lower level of the bay. You need to wait until you get the objective to “Engage the Cargo Crane.” At this point, you can start your quest to locate the Peng Treasure. Specifically, you want to enter the Cargo Bay, which is a part of the story mission in chapter 11. Once you do, you can head back to the chapter one area. This is quite a long way off if you just started playing, so simply make your way through the story until you reach chapter 11. It’s technically located in the first chapter of the game, but players won’t be able to actually retrieve it until chapter 11. Surprisingly, you don’t have to be in the game long before you can be in the same area as the Peng Treasure. The Peng Treasure in Dead Space Remake Provided by EA
0 kommentar(er)
